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Home - Products - Angiogenesis - Adrenergic Receptor - ARC 239 dihydrochloride

ARC 239 dihydrochloride

CAS No. 55974-42-0

ARC 239 dihydrochloride( ARC-239 | ARC239 )

Catalog No. M15036 CAS No. 55974-42-0

A potent, selective α2B adrenoceptor antagonist with pKd of 8.8, 200-fold selectivity over α2A, and α2D receptors.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    ARC 239 dihydrochloride
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent, selective α2B adrenoceptor antagonist with pKd of 8.8, 200-fold selectivity over α2A, and α2D receptors.
  • Description
    A potent, selective α2B adrenoceptor antagonist with pKd of 8.8, 200-fold selectivity over α2A, and α2D receptors; competitively antagonizes pressor responses to adrenaline and inhibits pressor responses to noradrenaline, phenylephrine, tyramine, and dimethylphenylpiperazinium in rats and dogs.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ARC-239 | ARC239
  • Pathway
    Angiogenesis
  • Target
    Adrenergic Receptor
  • Recptor
    Adrenergic Receptor
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    55974-42-0
  • Formula Weight
    480.43
  • Molecular Formula
    C24H29N3O3.2HCl
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 125 mg/mL (260.18 mM)
  • SMILES
    CC1(C2=CC=CC=C2C(=O)N(C1=O)CCN3CCN(CC3)C4=CC=CC=C4OC)C.Cl.Cl
  • Chemical Name
    2-[2-(4-(2-Methoxyphenyl)piperazin-1-yl)ethyl]-4,4-dimethyl-1,3-(2H,4H)-isoquinolindione dihydrochloride

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Mouillé P, et al. J Cardiovasc Pharmacol. 1980;2(2):175-91. 2. Bylund D, et al. J Pharmacol Exp Ther. 1988 May;245(2):600-7. 3. Bylund DB, et al. J Pharmacol Exp Ther. 1989 Nov;251(2):640-4.
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