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ARC 239 dihydrochloride
CAS No. 55974-42-0
ARC 239 dihydrochloride( ARC-239 | ARC239 )
Catalog No. M15036 CAS No. 55974-42-0
A potent, selective α2B adrenoceptor antagonist with pKd of 8.8, 200-fold selectivity over α2A, and α2D receptors.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 68 | Get Quote |
|
| 10MG | 120 | Get Quote |
|
| 25MG | 255 | Get Quote |
|
| 50MG | 410 | Get Quote |
|
| 100MG | 591 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameARC 239 dihydrochloride
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NoteResearch use only, not for human use.
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Brief DescriptionA potent, selective α2B adrenoceptor antagonist with pKd of 8.8, 200-fold selectivity over α2A, and α2D receptors.
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DescriptionA potent, selective α2B adrenoceptor antagonist with pKd of 8.8, 200-fold selectivity over α2A, and α2D receptors; competitively antagonizes pressor responses to adrenaline and inhibits pressor responses to noradrenaline, phenylephrine, tyramine, and dimethylphenylpiperazinium in rats and dogs.
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In Vitro——
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In Vivo——
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SynonymsARC-239 | ARC239
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PathwayAngiogenesis
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TargetAdrenergic Receptor
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RecptorAdrenergic Receptor
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Research Area——
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Indication——
Chemical Information
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CAS Number55974-42-0
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Formula Weight480.43
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Molecular FormulaC24H29N3O3.2HCl
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 125 mg/mL (260.18 mM)
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SMILESCC1(C2=CC=CC=C2C(=O)N(C1=O)CCN3CCN(CC3)C4=CC=CC=C4OC)C.Cl.Cl
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Chemical Name2-[2-(4-(2-Methoxyphenyl)piperazin-1-yl)ethyl]-4,4-dimethyl-1,3-(2H,4H)-isoquinolindione dihydrochloride
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Mouillé P, et al. J Cardiovasc Pharmacol. 1980;2(2):175-91.
2. Bylund D, et al. J Pharmacol Exp Ther. 1988 May;245(2):600-7.
3. Bylund DB, et al. J Pharmacol Exp Ther. 1989 Nov;251(2):640-4.
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