ARC 239 dihydrochloride
CAS No. 55974-42-0
ARC 239 dihydrochloride ( ARC-239;ARC239 )
Catalog No. M15036 CAS No. 55974-42-0
A potent, selective α2B adrenoceptor antagonist with pKd of 8.8, 200-fold selectivity over α2A, and α2D receptors.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
Size | Price / USD | Stock | Quantity |
5MG | 68 | Get Quote |
|
10MG | 120 | Get Quote |
|
25MG | 255 | Get Quote |
|
50MG | 410 | Get Quote |
|
100MG | 591 | Get Quote |
|
200MG | Get Quote | Get Quote |
|
500MG | Get Quote | Get Quote |
|
1G | Get Quote | Get Quote |
|
Biological Information
-
Product NameARC 239 dihydrochloride
-
NoteResearch use only, not for human use.
-
Brief DescriptionA potent, selective α2B adrenoceptor antagonist with pKd of 8.8, 200-fold selectivity over α2A, and α2D receptors.
-
DescriptionA potent, selective α2B adrenoceptor antagonist with pKd of 8.8, 200-fold selectivity over α2A, and α2D receptors; competitively antagonizes pressor responses to adrenaline and inhibits pressor responses to noradrenaline, phenylephrine, tyramine, and dimethylphenylpiperazinium in rats and dogs.
-
SynonymsARC-239;ARC239
-
PathwayAngiogenesis
-
TargetAdrenergic Receptor
-
RecptorAdrenergic Receptor
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number55974-42-0
-
Formula Weight480.43
-
Molecular FormulaC24H29N3O3.2HCl
-
Purity>98% (HPLC)
-
Solubility——
-
SMILESCC1(C2=CC=CC=C2C(=O)N(C1=O)CCN3CCN(CC3)C4=CC=CC=C4OC)C.Cl.Cl
-
Chemical Name2-[2-(4-(2-Methoxyphenyl)piperazin-1-yl)ethyl]-4,4-dimethyl-1,3-(2H,4H)-isoquinolindione dihydrochloride
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Mouillé P, et al. J Cardiovasc Pharmacol. 1980;2(2):175-91.
2. Bylund D, et al. J Pharmacol Exp Ther. 1988 May;245(2):600-7.
3. Bylund DB, et al. J Pharmacol Exp Ther. 1989 Nov;251(2):640-4.
2. Bylund D, et al. J Pharmacol Exp Ther. 1988 May;245(2):600-7.
3. Bylund DB, et al. J Pharmacol Exp Ther. 1989 Nov;251(2):640-4.
molnova catalog
related products
-
Milveterol hydrochlo...
Milveterol (GSK 159797) is a potent, selective long-acting β2 adrenoceptor agonist with pEC50 of 10.2 in cell-based assays, displays good β2/β1 selectivity.
-
nifenalol.HCl
Nifenalol is a antagonist of β-adrenergic receptor.
-
1-(2-Pyridyl)piperaz...
1-(2-Pyridyl)piperazine is a selective α2-adrenoceptor antagonists. 1-(2-Pyridyl)piperazine shows sympatholytic activity. 1-(2-Pyridyl)piperazine is also a metabolite of Azaperone.